This work is licensed under a Creative Commons Attribution 4.0 International License.
Peptide L6D/L12D/L17D/L20D/L21D
General Information
DRACP ID DRACP00429
Peptide Name Peptide L6D/L12D/L17D/L20D/L21D
Sequence KWKSFlKTFKSlKKTVlHTllKAISS
Sequence Length 26
UniProt ID Not available
PubChem CID Not available
Origin Acetylation
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=12.88±0.15 µmol/L | MTS assay | 1 h | 1 |
Hemolytic Activity Human red blood cells: MHC> 325.20 μmol/L
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification None
Chiral Mix
Physicochemical Information
Formula C115H177N31O24
Absent amino acids CDEGLMNPQRY
Common amino acids K
Mass 282393
Pl 11.58
Basic residues 8
Acidic residues 0
Hydrophobic residues 6
Net charge 8
Boman Index -4576
Hydrophobicity -79.23
Aliphatic Index 30
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 220
Polar residues 7
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22837667
Title Role of helicity on the anticancer mechanism of action of cationic-helical peptides
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.