This work is licensed under a Creative Commons Attribution 4.0 International License.
Latarcin 2a
General Information
DRACP ID DRACP00433
Peptide Name Latarcin 2a
Sequence GLFGKLIKKFGRKAISYAVKKARGKH
Sequence Length 26
UniProt ID Q1ELU1
PubChem CID Not available
Origin Central Asian spider, Lachesana tarabaevi
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Breast tumor cell | Breast tumor | Carcinoma | graph fig 8 A | LDH leakage assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C136H229N41O29
Absent amino acids CDEMNPQTW
Common amino acids K
Mass 334868
Pl 11.97
Basic residues 10
Acidic residues 0
Hydrophobic residues 10
Net charge 10
Boman Index -3802
Hydrophobicity -43.85
Aliphatic Index 82.69
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1490
Absorbance 280nm 59.6
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22885172
Title Imaging the membrane lytic activity of bioactive peptide latarcin 2a
Doi 10.1016/j.bbamem.2012.07.030
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.