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c3
General Information
DRACP ID DRACP00436
Peptide Name c3
Sequence KKXWKK
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Ramos | Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=15±2 μM | MTT assay | Not available | 1 |
| Ramos | Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=92±2 μM | MTT assay | Not available | 1 |
Hemolytic Activity Human red blood cells: EC50=256 μM
Normal (non-cancerous) Cytotoxicity MRC-5: IC50=1030±21 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Lys1<--->Lys6
N-terminal Modification lactam
C-terminal Modification lactam
Other Modification X=β2,2(2-Nal-CH2-)=(2,2-di(naphthalen-2-ylmethyl)-3-amino-propionic acid)
Chiral L
Physicochemical Information
Formula C35H58N10O5
Absent amino acids ACDEFGHILMNPQRSTVY
Common amino acids K
Mass 89827
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 1
Net charge 4
Boman Index -1987
Hydrophobicity -275
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 1100
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22933412
Title Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic β(2,2) -amino acid
Doi 10.1002/psc.2441
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.