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c4
General Information
DRACP ID DRACP00438
Peptide Name c4
Sequence KWXKK
Sequence Length 5
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Ramos | Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=12.6±0.6 μM | MTT assay | Not available | 1 |
| Ramos | Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=99±15 μM | MTT assay | Not available | 1 |
Hemolytic Activity Human red blood cells: EC50=110 μM
Normal (non-cancerous) Cytotoxicity MRC-5: IC50=23.5±0.7 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Lys1<--->Lys5
N-terminal Modification lactam
C-terminal Modification lactam
Other Modification X=β2,2(2-Nal-CH2-)=(2,2-di(naphthalen-2-ylmethyl)-3-amino-propionic acid)
Chiral L
Physicochemical Information
Formula C29H46N8O4
Absent amino acids ACDEFGHILMNPQRSTVY
Common amino acids K
Mass 75226
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 1
Net charge 3
Boman Index -1432
Hydrophobicity -252
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 1375
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 22933412
Title Improved anticancer potency by head-to-tail cyclization of short cationic anticancer peptides containing a lipophilic β(2,2) -amino acid
Doi 10.1002/psc.2441
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.