9R

General Information


DRACP ID  DRACP00444

Peptide Name   9R

Sequence  RRRRRNWMWC

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Nullomer derived anticancer peptides (NulloPs):

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
LNCaP Prostate carcinoma Carcinoma IC50=44 µM MTT assay 2 h 1
LNCaP Prostate carcinoma Carcinoma IC50=23 µM MTT assay 24 h 1
LNCaP Prostate carcinoma Carcinoma IC50=28 µM MTT assay 48 h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=39 µM MTT assay 2 h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=29 µM MTT assay 24 h 1
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=16 µM MTT assay 48 h 1
HuT 102 Mycosis fungoides; Classic mycosis fungoides Lymphoma IC50=93 µM MTT assay 2 h 1
HuT 102 Mycosis fungoides; Classic mycosis fungoides Lymphoma IC50=39 µM MTT assay 24 h 1
HuT 102 Mycosis fungoides; Classic mycosis fungoides Lymphoma IC50=37 µM MTT assay 48 h 1
HuT 102 Mycosis fungoides; Classic mycosis fungoides Lymphoma IC50=36 µM MTT assay 72 h 1
HuT 102 Mycosis fungoides; Classic mycosis fungoides Lymphoma IC50=25 µM MTT assay 96 h 1
J774A.1 Mouse reticulum cell sarcoma Sarcoma IC50=47 µM MTT assay 24 h 1
J774A.1 Mouse reticulum cell sarcoma Sarcoma IC50=12 µM MTT assay 96 h 1

Hemolytic Activity  no hemolytic effect on human RBCs

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00444

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C64H102N28O12S2

Absent amino acids  ADEFGHIKLPQSTVY

Common amino acids  R

Mass  168051

Pl  12.68

Basic residues  5

Acidic residues  0

Hydrophobic residues  2

Net charge  5

Boman Index  -7295

Hydrophobicity  -234

Aliphatic Index  0

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  1222.22

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 23000474

Title  Nullomer derived anticancer peptides (NulloPs): differential lethal effects on normal and cancer cells in vitro

Doi 10.1016/j.peptides.2012.09.015

Year  2012

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.