This work is licensed under a Creative Commons Attribution 4.0 International License.
9R
General Information
DRACP ID DRACP00444
Peptide Name 9R
Sequence RRRRRNWMWC
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Nullomer derived anticancer peptides (NulloPs):
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| LNCaP | Prostate carcinoma | Carcinoma | IC50=44 µM | MTT assay | 2 h | 1 |
| LNCaP | Prostate carcinoma | Carcinoma | IC50=23 µM | MTT assay | 24 h | 1 |
| LNCaP | Prostate carcinoma | Carcinoma | IC50=28 µM | MTT assay | 48 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=39 µM | MTT assay | 2 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=29 µM | MTT assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=16 µM | MTT assay | 48 h | 1 |
| HuT 102 | Mycosis fungoides; Classic mycosis fungoides | Lymphoma | IC50=93 µM | MTT assay | 2 h | 1 |
| HuT 102 | Mycosis fungoides; Classic mycosis fungoides | Lymphoma | IC50=39 µM | MTT assay | 24 h | 1 |
| HuT 102 | Mycosis fungoides; Classic mycosis fungoides | Lymphoma | IC50=37 µM | MTT assay | 48 h | 1 |
| HuT 102 | Mycosis fungoides; Classic mycosis fungoides | Lymphoma | IC50=36 µM | MTT assay | 72 h | 1 |
| HuT 102 | Mycosis fungoides; Classic mycosis fungoides | Lymphoma | IC50=25 µM | MTT assay | 96 h | 1 |
| J774A.1 | Mouse reticulum cell sarcoma | Sarcoma | IC50=47 µM | MTT assay | 24 h | 1 |
| J774A.1 | Mouse reticulum cell sarcoma | Sarcoma | IC50=12 µM | MTT assay | 96 h | 1 |
Hemolytic Activity no hemolytic effect on human RBCs
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C64H102N28O12S2
Absent amino acids ADEFGHIKLPQSTVY
Common amino acids R
Mass 168051
Pl 12.68
Basic residues 5
Acidic residues 0
Hydrophobic residues 2
Net charge 5
Boman Index -7295
Hydrophobicity -234
Aliphatic Index 0
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 1222.22
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23000474
Title Nullomer derived anticancer peptides (NulloPs): differential lethal effects on normal and cancer cells in vitro
Doi 10.1016/j.peptides.2012.09.015
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.