This work is licensed under a Creative Commons Attribution 4.0 International License.
Adenoregulin (DRS B2)
General Information
DRACP ID DRACP00446
Peptide Name Adenoregulin (DRS B2)
Sequence GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV
Sequence Length 33
UniProt ID Not available
PubChem CID Not available
Origin South American frog Phyllomedusa bicolor
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PC-3 | Prostate carcinoma | Carcinoma | GI50=1.24±0.23 µM | LDH leakage assay | 24 h | 1 |
| LNCaP | Prostate carcinoma | Carcinoma | GI50=0.31±0.15 µM | LDH leakage assay | 24 h | 1 |
| DU145 | Prostate carcinoma | Carcinoma | GI50=0.91±0.04 µM | LDH leakage assay | 24 h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | GI50=8.06±0.50 µM | LDH leakage assay | 24 h | 1 |
| Raji | EBV-related Burkitt lymphoma; Burkitt lymphoma | Lymphoma | GI50=2.57±0.75 µM | LDH leakage assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Drs B2 does not act by apoptosis but possibly by necrosis,antitumor and angiostatic activities
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C142H242N40O42
Absent amino acids CDFHMNPQRTY
Common amino acids A
Mass 375273
Pl 10.5
Basic residues 6
Acidic residues 3
Hydrophobic residues 18
Net charge 3
Boman Index -765
Hydrophobicity 19.7
Aliphatic Index 95.15
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 171.88
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23028527
Title Antitumor and angiostatic activities of the antimicrobial peptide dermaseptin B2
Doi 10.1371/journal.pone.0044351
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.