This work is licensed under a Creative Commons Attribution 4.0 International License.
(RW)3
General Information
DRACP ID DRACP00448
Peptide Name (RW)3
Sequence RWRWRW
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50=143±21µM | Resazurin assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=132±12µM | Resazurin assay | 48h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=159±7µM | Resazurin assay | 48h | 1 |
Hemolytic Activity Sheep erythrocytes: 50% Hemolysis=210 µM; Human erythrocytes: 17% Hemolysis=333 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C51H68N18O7
Absent amino acids ACDEFGHIKLMNPQSTVY
Common amino acids RW
Mass 113457
Pl 12.8
Basic residues 3
Acidic residues 0
Hydrophobic residues 3
Net charge 3
Boman Index -3777
Hydrophobicity -270
Aliphatic Index 0
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 3300
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23209509
Title Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups
Year 2012
Literature 2
Pubmed ID 17145799
Title Length effects in antimicrobial peptides of the (RW)n series
Year 2007
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.