This work is licensed under a Creative Commons Attribution 4.0 International License.
Epinecidin-8
General Information
DRACP ID DRACP00454
Peptide Name Epinecidin-8
Sequence FIFHIIKGLFHAGKMI
Sequence Length 16
UniProt ID Not available
PubChem CID Not available
Origin Epinephelus nebulosus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | ~70% Cytotoxicity=25 mg/L | MTS assay | 6 h | 1 |
| HT-1080 | Fibrosarcoma | Sarcoma | ~85% Cytotoxicity=25 mg/L | MTS assay | 6 h | 1 |
Hemolytic Activity EP-8 did not have a strong hemolytic effect at low doses
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C93H142N22O17S
Absent amino acids CDENPQRSTVWY
Common amino acids I
Mass 214010
Pl 10.81
Basic residues 4
Acidic residues 0
Hydrophobic residues 9
Net charge 4
Boman Index 1916
Hydrophobicity 118.13
Aliphatic Index 128.13
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23598079
Title Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus
Doi 10.1016/j.peptides.2013.04.004
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.