This work is licensed under a Creative Commons Attribution 4.0 International License.
Pardaxin-6
General Information
DRACP ID DRACP00455
Peptide Name Pardaxin-6
Sequence GFFALIPKIISSPLFKTLLSAVGSALS
Sequence Length 27
UniProt ID P81865 P81862 P81861
PubChem CID Not available
Origin Epinephelus nebulosus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | ~72% Cytotoxicity=25 mg/L | MTS assay | 6 h | 1 |
| HT-1080 | Fibrosarcoma | Sarcoma | ~84% Cytotoxicity=25 mg/L | MTS assay | 6 h | 1 |
Hemolytic Activity The HL50 values of Pardaxin-6 (about 100 mg/L) were much higher than those of EP-1 and EP-9
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C134H217N29O34
Absent amino acids CDEHMNQRWY
Common amino acids LS
Mass 324231
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 15
Net charge 2
Boman Index 2898
Hydrophobicity 125.93
Aliphatic Index 137.41
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23598079
Title Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus
Doi 10.1016/j.peptides.2013.04.004
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.