This work is licensed under a Creative Commons Attribution 4.0 International License.
Epinecidin-1
General Information
DRACP ID DRACP00457
Peptide Name Epinecidin-1
Sequence GFIFHIIKGLFHAGKMIHGLV
Sequence Length 21
UniProt ID Not available
PubChem CID Not available
Origin Epinephelus nebulosus
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | ~70% Cytotoxicity=25 mg/L | MTS assay | 6 h | 1 |
| HT-1080 | Fibrosarcoma | Sarcoma | ~90% Cytotoxicity=25 mg/L | MTS assay | 6 h | 1 |
Hemolytic Activity EP-1 did not have a strong hemolytic effect at low doses
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C114H175N29O22S
Absent amino acids CDENPQRSTWY
Common amino acids GI
Mass 269283
Pl 10.81
Basic residues 5
Acidic residues 0
Hydrophobic residues 11
Net charge 5
Boman Index 2534
Hydrophobicity 109.05
Aliphatic Index 130
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23598079
Title Truncated antimicrobial peptides from marine organisms retain anticancer activity and antibacterial activity against multidrug-resistant Staphylococcus aureus
Doi 10.1016/j.peptides.2013.04.004
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.