This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1CEa LK2(5)
General Information
DRACP ID DRACP00458
Peptide Name Temporin-1CEa LK2(5)
Sequence FKDLKKIANIINSIFKK
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic construct
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=44.7µM | MTT assay | 24h | 1 |
| BCaP-37 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=83.49µM | MTT assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=894.7µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: LC50=1186 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C96H162N24O23
Absent amino acids CEGHMPQRTVWY
Common amino acids K
Mass 230607
Pl 10.98
Basic residues 5
Acidic residues 1
Hydrophobic residues 8
Net charge 4
Boman Index -2078
Hydrophobicity -9.41
Aliphatic Index 120.59
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23609760
Title Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4538
This work is licensed under a Creative Commons Attribution 4.0 International License.