This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1CEa LK3
General Information
DRACP ID DRACP00459
Peptide Name Temporin-1CEa LK3
Sequence FKKLKKIANIINSIFKK
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin Synthetic construct
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=27.72µM | MTT assay | 24h | 1 |
| BCaP-37 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=25.04µM | MTT assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=224.8µM | MTT assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: LC50=4649 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C98H169N25O21
Absent amino acids CDEGHMPQRTVWY
Common amino acids K
Mass 231915
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 8
Net charge 6
Boman Index -1761
Hydrophobicity -11.76
Aliphatic Index 120.59
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23609760
Title Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_4540
This work is licensed under a Creative Commons Attribution 4.0 International License.