This work is licensed under a Creative Commons Attribution 4.0 International License.
Sungsanpin
General Information
DRACP ID DRACP00464
Peptide Name Sungsanpin
Sequence GFGSKPIDSFGLSWL
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Streptomyces
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | 10% Killing=50µM; 25% Inhibition=5µM(In a cell invasion assay); 30% Killing=100µM; 47% Inhibition=50µM(In a cell invasion assay) | CCK-8 assay; cell invasion assay kit(cell invasion) | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond LAC: Gly1<--->Asp8
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C77H111N17O21
Absent amino acids ACEHMNQRTVY
Common amino acids GS
Mass 186072
Pl 6.34
Basic residues 1
Acidic residues 1
Hydrophobic residues 6
Net charge 0
Boman Index 140
Hydrophobicity 28
Aliphatic Index 78
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 392.86
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23662937
Title Sungsanpin, a lasso peptide from a deep-sea streptomycete
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.