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TsAP-2 (T. serrulatus antimicrobial peptide 2)
General Information
DRACP ID DRACP00466
Peptide Name TsAP-2 (T. serrulatus antimicrobial peptide 2)
Sequence FLGMIPGLIGGLISAFK
Sequence Length 17
PubChem CID Not available
Origin Tityus serrulatus (Brazilian yellow scorpion)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=4.1μM | MTT assay | 24h | 1 |
| NCI-H838 | Lung adenocarcinoma | Carcinoma | IC50=11.0μM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=6.4μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=13.3μM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | Carcinoma | IC50=15.4μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes(possess little haemolytic activity (6.48%) at the highest concentration tested (160 μM) )
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticance; Antimicrobial; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C84H136N18O19S
Absent amino acids CDEHNQRTVWY
Common amino acids G
Mass 201976
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 9
Net charge 1
Boman Index 3445
Hydrophobicity 154.71
Aliphatic Index 143.53
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 23770440
Title Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities
Doi 10.1016/j.biochi.2013.06.003
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.