Peptide Libraray

TsAP-1 (T. serrulatus antimicrobial peptide 1)

General Information

DRACP ID DRACP00467

Peptide Name TsAP-1 (T. serrulatus antimicrobial peptide 1)

Sequence FLSLIPSLVGGSISAFK

Sequence Length 17

UniProt ID S6CWV8

PubChem CID Not available

Origin Tityus serrulatus (Brazilian yellow scorpion)

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	Carcinoma	IC50=55.9μM	MTT assay	24h	1
NCI-H838	Lung adenocarcinoma	Carcinoma	IC50=52.5μM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes(possess little haemolytic activity (6.48%) at the highest concentration tested (160 μM) )

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticance; Antimicrobial; Antibacterial

Structure Information

PDB ID Not available

Predicted Structure DRACP00467

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C83H134N18O22

Absent amino acids CDEHMNQRTWY

Common amino acids S

Mass 202165

Pl 9.7

Basic residues 1

Acidic residues 0

Hydrophobic residues 9

Net charge 1

Boman Index 1914

Hydrophobicity 132.35

Aliphatic Index 137.65

Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 23770440

Title Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: evaluation of their antimicrobial and anticancer activities

Doi 10.1016/j.biochi.2013.06.003

Year 2013

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available