This work is licensed under a Creative Commons Attribution 4.0 International License.
BP16
General Information
DRACP ID DRACP00469
Peptide Name BP16
Sequence KKLFKKILKKL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| CAPAN-1 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50>200 µM | MTT assay | 48 h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50>200 µM | MTT assay | 48 h | 1 |
Hemolytic Activity Human erythrocytes: 0% Hemolysis=150 µM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50>200 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H127N17O12
Absent amino acids ACDEGHMNPQRSTVWY
Common amino acids K
Mass 156543
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 5
Net charge 6
Boman Index -1064
Hydrophobicity -42.73
Aliphatic Index 141.82
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24480922
Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_6046
This work is licensed under a Creative Commons Attribution 4.0 International License.