This work is licensed under a Creative Commons Attribution 4.0 International License.
Bac2a [L2R][A3W][A11R]
General Information
DRACP ID DRACP00474
Peptide Name Bac2a [L2R][A3W][A11R]
Sequence RRWRIVVIRVRR
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>50 µM | Resazurin assay | 2h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>50 µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C74H133N31O13
Absent amino acids ACDEFGHKLMNPQSTY
Common amino acids R
Mass 186144
Pl 13.2
Basic residues 6
Acidic residues 0
Hydrophobic residues 6
Net charge 6
Boman Index -6523
Hydrophobicity -52.5
Aliphatic Index 137.5
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 500
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24038773
Title The antimicrobial activity of Sub3 is dependent on membrane binding and cell-penetrating ability
Year 2013
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.