This work is licensed under a Creative Commons Attribution 4.0 International License.
C -C8
General Information
DRACP ID DRACP00475
Peptide Name C -C8
Sequence RWRWRWX
Sequence Length 7
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=4.7µM | Crystal violet assay | 48h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | IC50=4.5µM | Crystal violet assay | 48h | 1 |
Hemolytic Activity Human erythrocytes:16% Hemolysis=142µM; 50% Hemolysis=285µM
Normal (non-cancerous) Cytotoxicity Human fibroblasts: IC50=31.3µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification X=Lysine with Octanoylated side group
Chiral L
Physicochemical Information
Formula C51H66N18O6
Absent amino acids ACDEFGHIKLMNPQSTVY
Common amino acids RW
Mass 124439
Pl 12.8
Basic residues 3
Acidic residues 0
Hydrophobic residues 3
Net charge 3
Boman Index -3777
Hydrophobicity -231.43
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 16500
Absorbance 280nm 2750
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24147906
Title Short antibacterial peptides with significantly reduced hemolytic activity can be identified by a systematic L-to-D exchange scan of their amino acid residues
Doi 10.1021/co400072q Abstract
Year 2013
Literature 2
Pubmed ID 24900420
Title Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain
Year 2012
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.