This work is licensed under a Creative Commons Attribution 4.0 International License.
Drosocin-1
General Information
DRACP ID DRACP00476
Peptide Name Drosocin-1
Sequence GKPRPYSPRPTSHPRPIRV
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Drosophila melanogaster; Drosophila simulans
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | Not active up to 600 µg/ml | Not available | Not available | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Not active up to 601 µg/ml | Not available | Not available | 1 |
Hemolytic Activity Mouse erythrocytes: <10% Hemolysis=100 µM; Pig erythrocytes: <10% Hemolysis=100 µM; Human erythrocytes: Not active up to 600 µg/ml
Normal (non-cancerous) Cytotoxicity CEM-SS cells: 50% Cell death>45.5 µM; HEK293: Not active up to 600 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C98H160N34O24
Absent amino acids ACDEFLMNQW
Common amino acids P
Mass 251976
Pl 12.51
Basic residues 6
Acidic residues 0
Hydrophobic residues 2
Net charge 6
Boman Index -6950
Hydrophobicity -157.89
Aliphatic Index 35.79
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 1490
Absorbance 280nm 82.78
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24164265
Title Hydroxyproline substitutions stabilize non-glycosylated drosocin against serum proteases without challenging its antibacterial activity
Doi 10.2174/09298665113206660105
Year 2014
Literature 2
Pubmed ID 31001677
Title The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum
Doi 10.1007/s00436-019-06305-x
Year 2019
Literature 3
Pubmed ID 20086159
Title Identification of novel human immunodeficiency virus type 1-inhibitory peptides based on the antimicrobial peptide database
Year 2010
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.