Short α-helical peptides

General Information


DRACP ID  DRACP00478

Peptide Name   Short α-helical peptides

Sequence  GIIKKIIKKI

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Alpha-helical proteins

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma 99% Cytotoxicity at 4 µM Approx MTT assay 24 h 1
HL-60 Adult acute myeloid leukemia; Acute myeloid leukemia Leukemia 100% Cytotoxicity at 5 µM Approx MTT assay 24 h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  In addition to rapid membrane-permeabilizing capacities, the peptides can also induce the programmed cell death of cancer cells via both mitochondrial pathway and death receptor pathway, without inducing non-specific immunogenic responses.

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00478

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C56H108N14O11

Absent amino acids  ACDEFHLMNPQRSTVWY

Common amino acids  I

Mass  131429

Pl  11.28

Basic residues  4

Acidic residues  0

Hydrophobic residues  5

Net charge  4

Boman Index  334

Hydrophobicity  65

Aliphatic Index  195

Half Life 
  Mammalian: 2.8 hour
  Yeast: 10 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24246647

Title  Molecular mechanisms of anticancer action and cell selectivity of short α-helical peptides

Doi 10.1016/j.biomaterials.2013.10.082

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.