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Short α-helical peptides
General Information
DRACP ID DRACP00478
Peptide Name Short α-helical peptides
Sequence GIIKKIIKKI
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Alpha-helical proteins
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 99% Cytotoxicity at 4 µM Approx | MTT assay | 24 h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 100% Cytotoxicity at 5 µM Approx | MTT assay | 24 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism In addition to rapid membrane-permeabilizing capacities, the peptides can also induce the programmed cell death of cancer cells via both mitochondrial pathway and death receptor pathway, without inducing non-specific immunogenic responses.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C56H108N14O11
Absent amino acids ACDEFHLMNPQRSTVWY
Common amino acids I
Mass 131429
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index 334
Hydrophobicity 65
Aliphatic Index 195
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24246647
Title Molecular mechanisms of anticancer action and cell selectivity of short α-helical peptides
Doi 10.1016/j.biomaterials.2013.10.082
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.