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Short α-helical peptides
General Information
DRACP ID DRACP00479
Peptide Name Short α-helical peptides
Sequence GIIKKIIKKIIKKI
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Alpha-helical proteins
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 95% Cytotoxicity at 4 µM Approx | MTT assay | 24 h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | 90% Cytotoxicity at 5 µM Approx | MTT assay | 24 h | 1 |
Hemolytic Activity Human erythrocytes: HC50>250 µM
Normal (non-cancerous) Cytotoxicity Human keratinocytes HaCat: <5% Killing=40 µM
Target Not available
Affinity Not available
Mechanism In addition to rapid membrane-permeabilizing capacities, the peptides can also induce the programmed cell death of cancer cells via both mitochondrial pathway and death receptor pathway, without inducing non-specific immunogenic responses.
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C80H154N20O15
Absent amino acids ACDEFHLMNPQRSTVWY
Common amino acids I
Mass 186831
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index 208
Hydrophobicity 55
Aliphatic Index 195
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24246647
Title Molecular mechanisms of anticancer action and cell selectivity of short α-helical peptides
Doi 10.1016/j.biomaterials.2013.10.082
Year 2014
Literature 2
Pubmed ID Not available
Title Amino acid side chains affect the bioactivity of designed short peptide amphiphiles
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.