This work is licensed under a Creative Commons Attribution 4.0 International License.
Cecropin A (2-8) + Melittin (6-9)
General Information
DRACP ID DRACP00481
Peptide Name Cecropin A (2-8) + Melittin (6-9)
Sequence WKLFKKILKVL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=18 µg/ml | MTT assay | Not available | 1 |
| LNCaP | Prostate carcinoma | Carcinoma | IC50=4 µg/ml | MTT assay | Not available | 1 |
| Raji | EBV-related Burkitt lymphoma; Burkitt lymphoma | Lymphoma | IC50=15 µg/ml | MTT assay | Not available | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=104 µM; 56% Hemolysis=150 µM
Normal (non-cancerous) Cytotoxicity CHO: 50% Cell death=13 µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C73H122N16O12
Absent amino acids ACDEGHMNPQRSTY
Common amino acids K
Mass 159443
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 7
Net charge 4
Boman Index 683
Hydrophobicity 58.18
Aliphatic Index 168.18
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 550
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24323118
Title Investigation of the antibacterial activity of a short cationic peptide against multidrug-resistant Klebsiella pneumoniae and Salmonella typhimurium strains and its cytotoxicity on eukaryotic cells
Year 2014
Literature 2
Pubmed ID 16672470
Title Inhibition of plant-pathogenic bacteria by short synthetic cecropin A-melittin hybrid peptides
Doi 10.1128/AEM.72.5.3302-3308.2006
Year 2006
Literature 3
Pubmed ID 19617390
Title Sporicidal activity of synthetic antifungal undecapeptides and control of Penicillium rot of apples
Year 2009
Literature 4
Title
Year
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.