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BP308
General Information
DRACP ID DRACP00483
Peptide Name BP308
Sequence RRLFRRILRRL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Cell-penetrating peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=148.2±8.8µM | MTT assay | 48h | 1 |
| CAPAN-1 | Pancreatic ductal adenocarcinoma | Carcinoma | IC50=97.0±15.4µM | MTT assay | 48h | 1 |
Hemolytic Activity Human erythrocytes: 1±0.1% Hemolysis=150µM
Normal (non-cancerous) Cytotoxicity NIH 3T3: IC50=68.0±7.6µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H127N29O12
Absent amino acids ACDEGHKMNPQSTVWY
Common amino acids R
Mass 173349
Pl 13.2
Basic residues 6
Acidic residues 0
Hydrophobic residues 5
Net charge 6
Boman Index -6686
Hydrophobicity -75.45
Aliphatic Index 141.82
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24480922
Title Identification of BP16 as a non-toxic cell-penetrating peptide with highly efficient drug delivery properties
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
DBAASP ID DBAASPS_10330
This work is licensed under a Creative Commons Attribution 4.0 International License.