This work is licensed under a Creative Commons Attribution 4.0 International License.
Dermaseptin S4 [M4K][N20K]
General Information
DRACP ID DRACP00487
Peptide Name Dermaseptin S4 [M4K][N20K]
Sequence ALWKTLLKKVLKAAAKAALKAVLVGANA
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | CC50=27.92 µg/ml | MTT assay | 0.5, 3, 6h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=0.5±0.2 µM
Normal (non-cancerous) Cytotoxicity Vero cells: 50% Cytotoxicity =25 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C135H238N36O31
Absent amino acids CDEFHIMPQRSY
Common amino acids A
Mass 334343
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 19
Net charge 6
Boman Index 1869
Hydrophobicity 81.07
Aliphatic Index 146.79
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 203.7
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24492362
Title In vitro activities of dermaseptins K4S4 and K4K20S4 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa planktonic growth and biofilm formation
Year 2014
Literature 2
Pubmed ID 10660589
Title Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity
Year 2000
Literature 3
Pubmed ID 11847217
Title Structural requirements for potent versus selective cytotoxicity for antimicrobial dermaseptin S4 derivatives
Year 2002
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.