This work is licensed under a Creative Commons Attribution 4.0 International License.
Dermaseptin S4 [M4K]
General Information
DRACP ID DRACP00488
Peptide Name Dermaseptin S4 [M4K]
Sequence ALWKTLLKKVLKAAAKAALNAVLVGANA
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 50% Cytotoxicity=28.11 µg/ml | MTT assay | 0.5, 3, 6h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis=2±0.1 µM
Normal (non-cancerous) Cytotoxicity BHK-21 BSR: 10.5% Cytotoxicity =10 µM; Vero cells: 50% Cytotoxicity =12 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C133H232N36O32
Absent amino acids CDEFHIMPQRSY
Common amino acids A
Mass 332936
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 19
Net charge 5
Boman Index 1760
Hydrophobicity 82.5
Aliphatic Index 146.79
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 203.7
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24492362
Title In vitro activities of dermaseptins K4S4 and K4K20S4 against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa planktonic growth and biofilm formation
Year 2014
Literature 2
Pubmed ID 10660589
Title Structure-activity relationship study of antimicrobial dermaseptin S4 showing the consequences of peptide oligomerization on selective cytotoxicity
Year 2000
Literature 3
Pubmed ID 23161023
Title In vitro antiviral activity of dermaseptin S(4) and derivatives from amphibian skin against herpes simplex virus type 2
Year 2013
Literature 4
Pubmed ID 29439871
Title Dermaseptins as potential antirabies compounds
Doi 10.1016/j.vaccine.2018.01.066
Year 2019
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.