This work is licensed under a Creative Commons Attribution 4.0 International License.
cyclosaplin
General Information
DRACP ID DRACP00490
Peptide Name cyclosaplin
Sequence RLGDGCTR
Sequence Length 8
UniProt ID Not available
PubChem CID Not available
Origin somatic seedlings of sandalwood
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=2.06 μg/mL | MTT assay | 24-72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Normal fibroblast (L929) cell line: Peptide (0–1000 μg/mL) did not exhibit any cytotoxicity.
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C33H60N14O12S
Absent amino acids AEFHIKMNPQSVWY
Common amino acids GR
Mass 100203
Pl 8.55
Basic residues 2
Acidic residues 1
Hydrophobic residues 1
Net charge 1
Boman Index -3305
Hydrophobicity -96.25
Aliphatic Index 48.75
Half Life
Mammalian: 7.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24503375
Title Identification and structural characterization of a new pro-apoptotic cyclic octapeptide cyclosaplin from somatic seedlings of Santalum album L
Doi 10.1016/j.peptides.2014.01.023
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.