This work is licensed under a Creative Commons Attribution 4.0 International License.
Trichoplaxin
General Information
DRACP ID DRACP00491
Peptide Name Trichoplaxin
Sequence FFGRLKSVWSAVKHGWKAAKSR
Sequence Length 22
UniProt ID Not available
PubChem CID Not available
Origin Trichoplax adhaerens
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=45-50µM | MTT assay | 24h | 1 |
Hemolytic Activity Rat erythrocytes:20% Hemolysis=800µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C120H184N36O26
Absent amino acids CDEIMNPQTY
Common amino acids K
Mass 292175
Pl 12.56
Basic residues 7
Acidic residues 0
Hydrophobic residues 10
Net charge 7
Boman Index -3597
Hydrophobicity -43.64
Aliphatic Index 57.73
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 523.81
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24530880
Title Trichoplaxin - a new membrane-active antimicrobial peptide from placozoan Cdna
Doi 10.1016/j.bbamem.2014.02.003
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.