Peptide Libraray

Pexiganan

General Information

DRACP ID DRACP00493

Peptide Name Pexiganan

Sequence GIGKFLKKAKKFGKAFVKILKK

Sequence Length 22

UniProt ID Not available

PubChem CID Not available

Origin Analog of magainin 2

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	LC50=8 at 100 µM	MTS assay	72 h	1
LNCaP	Prostate carcinoma	Carcinoma	LC50=6 at 100 µM	MTS assay	72 h	1
OVCAR-3	High grade ovarian serous adenocarcinoma	Carcinoma	LC50=13 at 100 µM	MTS assay	72 h	1

Hemolytic Activity Human red blood cells: HC10=70 µM, HC10 is concentration causing 10% hemolysis of human red blood cells

Normal (non-cancerous) Cytotoxicity Primary dermal fibroblast: LC50=19 at 100 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00493

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C122H209N31O23

Absent amino acids CDEHMNPQRSTWY

Common amino acids K

Mass 285296

Pl 11.7

Basic residues 9

Acidic residues 0

Hydrophobic residues 10

Net charge 9

Boman Index -1085

Hydrophobicity -15.91

Aliphatic Index 93.18

Half Life
Mammalian: 3.5 hour
Yeast: 10 min
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 24587350

Title Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity

Doi 10.1371/journal.pone.0090397

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available