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LL 37
General Information
DRACP ID DRACP00494
Peptide Name LL 37
Sequence LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES
Sequence Length 37
PubChem CID Not available
Origin Also known human cathelicidin
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | LC50=21 at 100 µM | MTS assay | 72 h | 1 |
| LNCaP | Prostate carcinoma | Carcinoma | LC50=27 at 100 µM | MTS assay | 72 h | 1 |
| OVCAR-3 | High grade ovarian serous adenocarcinoma | Carcinoma | LC50=24 at 100 µM | MTS assay | 72 h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Primary dermal fibroblast: LC50=26 at 100 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C205H340N60O53
Absent amino acids ACHMWY
Common amino acids K
Mass 513561
Pl 11.35
Basic residues 11
Acidic residues 5
Hydrophobic residues 13
Net charge 6
Boman Index -11100
Hydrophobicity -72.43
Aliphatic Index 89.46
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24587350
Title Learning from host-defense peptides: cationic, amphipathic peptoids with potent anticancer activity
Doi 10.1371/journal.pone.0090397
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
External Code
This work is licensed under a Creative Commons Attribution 4.0 International License.