This work is licensed under a Creative Commons Attribution 4.0 International License.
Cathelicidin-RC1
General Information
DRACP ID DRACP00495
Peptide Name Cathelicidin-RC1
Sequence KKCKFFCKVKKKIKSIGFQIPIVSIPFK
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Lithobates catesbeiana
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | At 200 µg/ml induced 4.3% cell death | MTT assay | 48h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | At 200 µg/ml induced 2.5% cell death | MTT assay | 48h | 1 |
Hemolytic Activity Human erythrocytes:0% Hemolysis=100µg/ml; 3% Hemolysis=200µg/ml
Normal (non-cancerous) Cytotoxicity L929: At 200 µg/ml induced 1.1% cell death
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C159H264N38O32S2
Absent amino acids ADEHLMNRTWY
Common amino acids K
Mass 376597
Pl 11.1
Basic residues 9
Acidic residues 0
Hydrophobic residues 11
Net charge 9
Boman Index -1419
Hydrophobicity 11.79
Aliphatic Index 90.36
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 4.63
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24675879
Title Cathelicidins from the bullfrog Rana catesbeiana provides novel template for peptide antibiotic design
Doi 10.1371/journal.pone.0093216
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.