Peptide Libraray

Chrysophsin-1

General Information

DRACP ID DRACP00497

Peptide Name Chrysophsin-1

Sequence FFGWLIKGAIHAGKAIHGLIHRRRH

Sequence Length 25

UniProt ID Not available

PubChem CID Not available

Origin Red sea bream

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
DU145	Prostate carcinoma	Carcinoma	~87%Inhibit=5 µg/mL	MTS assay	24 h	1
DU145	Prostate carcinoma	Carcinoma	~87%Inhibit=5 µg/mL	MTS assay	24 h	1
DU145	Prostate carcinoma	Carcinoma	~87%Inhibit=5 µg/mL	MTS assay	24 h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity NIH3T3: ~35%Inhibit=5 µg/mL; WS-1: ~42%Inhibit=5 µg/mL

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00497

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C136H211N45O26

Absent amino acids CDEMNPQSTVY

Common amino acids GHI

Mass 332075

Pl 12.81

Basic residues 9

Acidic residues 0

Hydrophobic residues 12

Net charge 9

Boman Index -2750

Hydrophobicity 0

Aliphatic Index 105.6

Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 5500

Absorbance 280nm 229.17

Polar residues 4

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 21349308

Title Characteristics of the antitumor activities in tumor cells and modulation of the inflammatory response in RAW264.7 cells of a novel antimicrobial peptide, chrysophsin-1, from the red sea bream (Chrysophrys major)

Doi 10.1016/j.peptides.2011.02.013

Year 2011

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available