This work is licensed under a Creative Commons Attribution 4.0 International License.
mt_S20A/L22 W/P27A
General Information
DRACP ID DRACP00500
Peptide Name mt_S20A/L22 W/P27A
Sequence ETFADWWKLLAE
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin MDM2
Type Synthetic peptide
Classification
Active ACP Cancer targeted peptides
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=8.7 µM | MTT assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target MDM2
Affinity Not available
Mechanism target the p53–MDM5 interaction
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C73H101N15O20
Absent amino acids CGHIMNPQRSVY
Common amino acids AELW
Mass 170509
Pl 3.93
Basic residues 1
Acidic residues 3
Hydrophobic residues 7
Net charge -2
Boman Index -936
Hydrophobicity -24.17
Aliphatic Index 81.67
Half Life
Mammalian: 1 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 11000
Absorbance 280nm 1000
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24830845
Title Design of p53-derived peptides with cytotoxicity on breast cancer
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.