mt_L22 W/P27A

General Information


DRACP ID  DRACP00501

Peptide Name   mt_L22 W/P27A

Sequence  ETFSDWWKLLAE

Sequence Length  12

UniProt ID  Not available

PubChem CID  Not available

Origin  MDM2

Type  Synthetic peptide

Classification

  

Active ACP Cancer targeted peptides



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=16.3 µM MTT assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  MDM2

Affinity  Not available

Mechanism  target the p53–MDM2 interaction

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00501

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C73H101N15O21

Absent amino acids  CGHIMNPQRVY

Common amino acids  ELW

Mass  172108

Pl  3.93

Basic residues  1

Acidic residues  3

Hydrophobic residues  6

Net charge  -2

Boman Index  -1457

Hydrophobicity  -45.83

Aliphatic Index  73.33

Half Life 
  Mammalian: 1 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  11000

Absorbance 280nm  1000

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 24830845

Title  Design of p53-derived peptides with cytotoxicity on breast cancer

Doi 10.1007/s00726-014-1750-y

Year  2014 

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.