This work is licensed under a Creative Commons Attribution 4.0 International License.
Latarcin-1
General Information
DRACP ID DRACP00503
Peptide Name Latarcin-1
Sequence SMWSGMWRRKLKKLRNALKKKLKGE
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Lachesana tarabaevi
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | 50% Cell death=52.51±3.6 µM | Non-Radioactive Cell Proliferation assay | 72h | 1 |
Hemolytic Activity Rabbit erythrocytes: 20% Hemolysis=80 µM; Human erythrocytes: 36% Hemolysis=256 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C138H238N44O31S2
Absent amino acids CDFHIPQTVY
Common amino acids K
Mass 350206
Pl 12.33
Basic residues 10
Acidic residues 1
Hydrophobic residues 7
Net charge 9
Boman Index -7113
Hydrophobicity -124.8
Aliphatic Index 66.4
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 458.33
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24885331
Title Identification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus
Year 2014
Literature 2
Pubmed ID 16735513
Title Latarcins, antimicrobial and cytolytic peptides from the venom of the spider Lachesana tarabaevi (Zodariidae) that exemplify biomolecular diversity
Year 2006
Literature 3
Pubmed ID 34576320
Title Membrane Interactions of Latarcins: Antimicrobial Peptides from Spider Venom
Year 2021
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.