This work is licensed under a Creative Commons Attribution 4.0 International License.
C7A-D21K
General Information
DRACP ID DRACP00506
Peptide Name C7A-D21K
Sequence KILRGVAKKIMRTFLRRISKKILTGKK
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HCT 116 | Colon carcinoma | Carcinoma | Cell viability=50% at 12.5μM approx. | Cell Viability assay | 1 h | 1 |
| HROC24 | Colon adenocarcinoma | Carcinoma | Cell viability >50% at 25μM approx | Cell Viability assay | 1 h | 1 |
| HROC40 | Colon adenocarcinoma | Carcinoma | Cell viability >50% at 25μM approx | Cell Viability assay | 1 h | 1 |
| HROC60 | Colon adenocarcinoma | Carcinoma | Cell viability >50% at 25μM approx | Cell Viability assay | 1 h | 1 |
| HROC32 | Colon adenocarcinoma | Carcinoma | Cell viability=50% at 12.5μM approx. | Cell Viability assay | 1 h | 1 |
| HCT 116 | Colon carcinoma | Carcinoma | Cell viability >40% at 12.5μM approx | Cell Viability assay | 24 h | 1 |
| HROC18 | Cecum adenocarcinoma | Carcinoma | Cell viability >55% at 12.5μM approx | Cell Viability assay | 24 h | 1 |
| HROC24 | Colon adenocarcinoma | Carcinoma | Cell viability >55% at 12.5μM approx | Cell Viability assay | 24 h | 1 |
| HROC40 | Colon adenocarcinoma | Carcinoma | Cell viability >80% at 12.5μM approx | Cell Viability assay | 24 h | 1 |
| HROC60 | Colon adenocarcinoma | Carcinoma | Cell viability >60% at 12.5μM approx | Cell Viability assay | 24 h | 1 |
| HROC113 | Colon adenocarcinoma; Lynch syndrome | Carcinoma | Cell viability >65% at 12.5μM approx | Cell Viability assay | 24 h | 1 |
| HROC32 | Colon adenocarcinoma | Carcinoma | Cell viability >80% at 12.5μM approx | Cell Viability assay | 24 h | 1 |
| HROC107 | Colon adenocarcinoma | Carcinoma | Cell viability >65% at 12.5μM approx | Cell Viability assay | 24 h | 1 |
Hemolytic Activity Whole blood cells: experiments revealed absent or minimal hemolysis
Normal (non-cancerous) Cytotoxicity lymphotoxic effects in vitro
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C145H268N46O31S
Absent amino acids CDEHNPQWY
Common amino acids K
Mass 364801
Pl 13
Basic residues 11
Acidic residues 0
Hydrophobic residues 10
Net charge 11
Boman Index -5957
Hydrophobicity -30.37
Aliphatic Index 115.56
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 24962950
Title Host defense peptides for treatment of colorectal carcinoma - a comparative in vitro and in vivo analysis
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.