This work is licensed under a Creative Commons Attribution 4.0 International License.
3-OH-C16-KKKK
General Information
DRACP ID DRACP00509
Peptide Name 3-OH-C16-KKKK
Sequence KKKK
Sequence Length 4
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | 25% Cytotoxicity=80µM | Colorimetric detection assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | CC50>30µM | MTS assay | 48h | 2 |
| DU145 | Prostate carcinoma | Carcinoma | CC50>30µM | MTS assay | 48h | 2 |
| Mia PaCa-2 | Pancreatic ductal adenocarcinoma | Carcinoma | CC50>30µM | MTS assay | 48h | 2 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification 3-OH-C16
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C24H50N8O5
Absent amino acids ACDEFGHILMNPQRSTVWY
Common amino acids K
Mass 58440
Pl 11.28
Basic residues 4
Acidic residues 0
Hydrophobic residues 0
Net charge 4
Boman Index -2220
Hydrophobicity -390
Aliphatic Index 0
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25069750
Title Structure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity
Year 2014
Literature 2
Pubmed ID 27486068
Title Ultrashort cationic lipopeptides and lipopeptoids: Evaluation and mechanistic insights against epithelial cancer cells
Doi 10.1016/j.peptides.2016.07.007
Year 2016
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.