Peptide Libraray

Hymenochirin-1Pa

General Information

DRACP ID DRACP00511

Peptide Name Hymenochirin-1Pa

Sequence LKLSPKTKDTLKKVLKGAIKGAIAIASMA

Sequence Length 29

UniProt ID Not available

PubChem CID Not available

Origin skin secretions of the frog Pseudhymenochirus merlini (Pipidae)

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Carcinoma	LC50=1.2±0.2 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1
MDA-MB-231	Breast adenocarcinoma	Carcinoma	LC50=3.1±0.2 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1
HT-29	Colon adenocarcinoma	Carcinoma	LC50=12.3±4.7 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1

Hemolytic Activity Human red blood cells (RBC): LC50=162±13 μM

Normal (non-cancerous) Cytotoxicity HUVEC: LC50=7.7±0.7 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00511

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C136H248N36O36S

Absent amino acids CEFHNQRWY

Common amino acids K

Mass 349539

Pl 11.2

Basic residues 7

Acidic residues 1

Hydrophobic residues 13

Net charge 6

Boman Index -775

Hydrophobicity 26.21

Aliphatic Index 121.38

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25241629

Title Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa

Doi 10.1016/j.peptides.2014.08.017

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available