This work is licensed under a Creative Commons Attribution 4.0 International License.
[D9K]Hymenochirin-1Pa
General Information
DRACP ID DRACP00512
Peptide Name [D9K]Hymenochirin-1Pa
Sequence LKLSPKTKKTLKKVLKGAIKGAIAIASMA
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin skin secretions of the frog Pseudhymenochirus merlini (Pipidae)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=0.9±0.3 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=2.4±0.1 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | LC50=3.9±0.4 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
Hemolytic Activity Human red blood cells (RBC): LC50=192±21 μM
Normal (non-cancerous) Cytotoxicity HUVEC: LC50=6.5±0.2 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C138H255N37O34S
Absent amino acids CDEFHNQRWY
Common amino acids K
Mass 350847
Pl 11.65
Basic residues 8
Acidic residues 0
Hydrophobic residues 13
Net charge 8
Boman Index -458
Hydrophobicity 24.83
Aliphatic Index 121.38
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25241629
Title Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa
Doi 10.1016/j.peptides.2014.08.017
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.