Peptide Libraray

[D9k]Hymenochirin-1Pa

General Information

DRACP ID DRACP00513

Peptide Name [D9k]Hymenochirin-1Pa

Sequence LKLSPKTKkTLKKVLKGAIKGAIAIASMA

Sequence Length 29

UniProt ID Not available

PubChem CID Not available

Origin skin secretions of the frog Pseudhymenochirus merlini (Pipidae)

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Carcinoma	LC50=2.5±0.3 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1
MDA-MB-231	Breast adenocarcinoma	Carcinoma	LC50=5.4±0.4 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1
HT-29	Colon adenocarcinoma	Carcinoma	LC50=6.3±1.9 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1

Hemolytic Activity Human red blood cells (RBC): LC50>400 μM

Normal (non-cancerous) Cytotoxicity HUVEC: LC50=9.3±0.3 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification k=D-Lys

Chiral Mix

Physicochemical Information

Formula C132H241N35O32S

Absent amino acids CDEFHNQRWY

Common amino acids K

Mass 336228

Pl 11.58

Basic residues 7

Acidic residues 0

Hydrophobic residues 13

Net charge 7

Boman Index 97

Hydrophobicity 38.28

Aliphatic Index 121.38

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 6

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25241629

Title Conformational analysis and cytotoxic activities of the frog skin host-defense peptide, hymenochirin-1Pa

Doi 10.1016/j.peptides.2014.08.017

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available