This work is licensed under a Creative Commons Attribution 4.0 International License.
Mastoparan
General Information
DRACP ID DRACP00514
Peptide Name Mastoparan
Sequence INLKALAALAKKIL
Sequence Length 14
UniProt ID P01514
PubChem CID 6324633
Origin Vespula lewisii
Type Native peptide
Classification
Active ACP Cell-penetrating peptides Induce apoptosis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=432.5 µM | MTT assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | IC50=251.25 µM | MTT assay | 24h | 1 |
| SiHa | Human papillomavirus-related cervical squamous cell carcinoma; Squamous cell carcinoma of the cervix uteri | Carcinoma | IC50=172.1 µM | MTT assay | 24h | 1 |
| SK-BR-3 | Breast adenocarcinoma | Carcinoma | IC50=320.3 µM | MTT assay | 24h | 1 |
| U-87MG ATCC | Glioblastoma | Blastoma | IC50=311.7 µM | MTT assay | 24h | 1 |
| Jurkat | Childhood T acute lymphoblastic leukemia; Precursor T-cell acute lymphoblastic leukemia | Leukemia | IC50=77.9 µM | MTT assay | 24h | 1 |
| A2058 | Amelanotic melanoma | Carcinoma | IC50=140 µM | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity non-tumor cells (melan-a and HaCaT) were more resistant to mastoparan treatment, and their IC50 values were 411.5 and 428 μM
Target Not available
Affinity Not available
Mechanism Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C70H130N18O16
Absent amino acids CDEFGHMPQRSTVWY
Common amino acids AL
Mass 171201
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 10
Net charge 3
Boman Index 1347
Hydrophobicity 115.71
Aliphatic Index 195.71
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25305549
Title Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo
Doi 10.1016/j.bbamem.2015.07.018
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.