Peptide Libraray

Ps-2Pa

General Information

DRACP ID DRACP00515

Peptide Name Ps-2Pa

Sequence GIFPIFAKLLGKVIKVASSLISKGRTE

Sequence Length 27

UniProt ID Not available

PubChem CID Not available

Origin skin secretions of the frog Pseudhymenochirus merlini (Pipidae)

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
A549	Lung adenocarcinoma	Carcinoma	LC50=6.0±0.6 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1
MDA-MB-231	Breast adenocarcinoma	Carcinoma	LC50=6.2±0.6 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1
HT-29	Colon adenocarcinoma	Carcinoma	LC50=11.5±2.6 μM	CellTiter-Glo Luminescent Cell Viability assay	24h	1

Hemolytic Activity Human erythrocytes: LC50=6.2±1.0 μM

Normal (non-cancerous) Cytotoxicity HUVEC: LC50=68±2 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00515

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C135H230N34O34

Absent amino acids CDHMNQWY

Common amino acids IK

Mass 333746

Pl 11.25

Basic residues 5

Acidic residues 1

Hydrophobic residues 13

Net charge 4

Boman Index -178

Hydrophobicity 64.81

Aliphatic Index 130

Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 7

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 25447194

Title Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa

Doi 10.1016/j.regpep.2014.11.001

Year 2014

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available