This work is licensed under a Creative Commons Attribution 4.0 International License.
Ps-1Pb
General Information
DRACP ID DRACP00516
Peptide Name Ps-1Pb
Sequence IKIPSFFRNILKKVGKEAVSLIAGALKQS
Sequence Length 29
UniProt ID Not available
PubChem CID Not available
Origin skin secretions of the frog Pseudhymenochirus merlini (Pipidae)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | LC50=2.5±0.2 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=6.6±0.3 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | LC50=9.5±1.3 μM | CellTiter-Glo Luminescent Cell Viability assay | 24h | 1 |
Hemolytic Activity Human red blood cells (RBC): LC50>403 μM
Normal (non-cancerous) Cytotoxicity HUVEC: LC50=5.6±0.9 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C147H251N39O37
Absent amino acids CDHMTWY
Common amino acids K
Mass 365647
Pl 11.37
Basic residues 6
Acidic residues 1
Hydrophobic residues 14
Net charge 5
Boman Index -1607
Hydrophobicity 32.76
Aliphatic Index 124.48
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25447194
Title Anti-cancer, immunoregulatory, and antimicrobial activities of the frog skin host-defense peptides pseudhymenochirin-1Pb and pseudhymenochirin-2Pa
Doi 10.1016/j.regpep.2014.11.001
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.