This work is licensed under a Creative Commons Attribution 4.0 International License.
B1-Phe
General Information
DRACP ID DRACP00520
Peptide Name B1-Phe
Sequence VKRFKKFFRKLKKFV
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin Cathelicidin-BF15 C-terminal amidated derivative B1
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=1.3 µM | MTT assay | 48h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=3.7 µM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity GES-1: IC50=107.2 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C100H163N27O16
Absent amino acids ACDEGHIMNPQSTWY
Common amino acids K
Mass 224944
Pl 12.58
Basic residues 8
Acidic residues 0
Hydrophobic residues 7
Net charge 8
Boman Index -3822
Hydrophobicity -60
Aliphatic Index 64.67
Half Life
Mammalian: 100 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25462264
Title Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities
Doi 10.1016/j.ejmech.2014.10.072
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.