GN-8
General Information
DRACP ID DRACP00532
Peptide Name GN-8
Sequence IWKRWWWKR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
---|---|---|---|---|---|---|
HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=199µg/ml | MTT assay | 1h | 1 |
Hemolytic Activity Human erythrocytes:<=10% Hemolysis>400µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C74H101N21O10
Absent amino acids ACDEFGHLMNPQSTVY
Common amino acids W
Mass 158762
Pl 12.53
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index -2670
Hydrophobicity -176.67
Aliphatic Index 43.33
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 22000
Absorbance 280nm 2750
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25941221
Title Antimicrobial activity of GN peptides and their mode of action
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available