GN-5

General Information


DRACP ID  DRACP00533

Peptide Name   GN-5

Sequence  KKRWWWWWR

Sequence Length  9

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=131µg/ml MTT assay 1h 1

Hemolytic Activity  Human erythrocytes:<=10% Hemolysis=100µg/ml

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00533

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C79H100N22O10

Absent amino acids  ACDEFGHILMNPQSTVY

Common amino acids  W

Mass  166067

Pl  12.53

Basic residues  4

Acidic residues  0

Hydrophobic residues  5

Net charge  4

Boman Index  -2929

Hydrophobicity  -236.67

Aliphatic Index  0

Half Life 
  Mammalian: 20 hour
  Yeast: 30 min
  E.coli: >10 hour

Extinction Coefficient cystines  27500

Absorbance 280nm  3437.5

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 25941221

Title  Antimicrobial activity of GN peptides and their mode of action

Doi 10.1128/AAC.00237-15

Year  2015

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.