This work is licensed under a Creative Commons Attribution 4.0 International License.
GN-14
General Information
DRACP ID DRACP00538
Peptide Name GN-14
Sequence RLWKRWWIR
Sequence Length 9
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50>200µg/ml | MTT assay | 1h | 1 |
Hemolytic Activity Human erythrocytes:<10% Hemolysis>400µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H102N22O10
Absent amino acids ACDEFGHMNPQSTVY
Common amino acids RW
Mass 154258
Pl 12.81
Basic residues 4
Acidic residues 0
Hydrophobic residues 5
Net charge 4
Boman Index -3348
Hydrophobicity -131.11
Aliphatic Index 86.67
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 16500
Absorbance 280nm 2062.5
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25941221
Title Antimicrobial activity of GN peptides and their mode of action
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.