This work is licensed under a Creative Commons Attribution 4.0 International License.
DM1
General Information
DRACP ID DRACP00545
Peptide Name DM1
Sequence GLFDKWAWWRWRR
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=215.3±19.7µg/ml | CellTiter 96® AQueous Non-Radioactive Cell Proliferation assay | 24h | 1 |
Hemolytic Activity Human erythrocytes:10% Hemolysis>250µg/ml; 50% Hemolysis>250µg/ml
Normal (non-cancerous) Cytotoxicity NL20: 50% Cell death=221.8±7.8µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C92H123N27O16
Absent amino acids CEHIMNPQSTVY
Common amino acids W
Mass 207738
Pl 12.22
Basic residues 4
Acidic residues 1
Hydrophobic residues 7
Net charge 3
Boman Index -3906
Hydrophobicity -126.92
Aliphatic Index 37.69
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 22000
Absorbance 280nm 1833.33
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 25985150
Title In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.