This work is licensed under a Creative Commons Attribution 4.0 International License.
Compound 5
General Information
DRACP ID DRACP00548
Peptide Name Compound 5
Sequence RTXCXfLRXC
Sequence Length 10
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| PC-12 | Lung papillary adenocarcinoma | Carcinoma | IC50=629µg/ml | WST-1 assay | Not available | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Madin-Darby canine kidney cells: IC50=548µg/ml; Human dermal fibroblasts: IC50=534µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<---Cys10
N-terminal Modification C9
C-terminal Modification Amidation
Other Modification X=diaminobutyrate; f=D-Phe
Chiral Mix
Physicochemical Information
Formula C28H46N12O4S2
Absent amino acids ADEFGHIKMNPQSVWY
Common amino acids X
Mass 116958
Pl 8.83
Basic residues 2
Acidic residues 0
Hydrophobic residues 1
Net charge 2
Boman Index -2493
Hydrophobicity -9
Aliphatic Index 39
Half Life
/
Extinction Coefficient cystines 125
Absorbance 280nm 13.89
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26024044
Title A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicity
Year 2015
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.