This work is licensed under a Creative Commons Attribution 4.0 International License.
KL15
General Information
DRACP ID DRACP00553
Peptide Name KL15
Sequence KRKLYKWFAHLIKGL
Sequence Length 15
UniProt ID Not available
PubChem CID Not available
Origin membrane disrupting antimicrobial peptide KL15
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SW480 | Colon adenocarcinoma | Carcinoma | IC50=50 mg/ml | MTT assay | 24h | 1 |
| CaCo-2 | Colon adenocarcinoma | Carcinoma | IC50=50 mg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity H184B5F5/M10: IC50=150 μg/ml, testing time is 24h
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C94H149N25O17
Absent amino acids CDEMNPQSTV
Common amino acids K
Mass 215128
Pl 11.28
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index -1418
Hydrophobicity -36
Aliphatic Index 110.67
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 6990
Absorbance 280nm 499.29
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26147829
Title Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15
Doi 10.1080/15384047.2015.1056407
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.