m4

General Information


DRACP ID  DRACP00555

Peptide Name   m4

Sequence  LRRLDRWLRLFNRLRRWFLRLLRGL

Sequence Length  25

UniProt ID  Not available

PubChem CID  Not available

Origin  membrane disrupting antimicrobial peptide KL15

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
SW480 Colon adenocarcinoma Carcinoma IC50=110 mg/ml MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00555

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C158H261N55O29

Absent amino acids  ACEHIKMPQSTVY

Common amino acids  LR

Mass  382342

Pl  13.04

Basic residues  9

Acidic residues  1

Hydrophobic residues  13

Net charge  8

Boman Index  -9380

Hydrophobicity  -39.6

Aliphatic Index  140.4

Half Life 
  Mammalian: 5.5 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  11000

Absorbance 280nm  458.33

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 26147829

Title  Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15

Doi 10.1080/15384047.2015.1056407

Year  2014

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.