This work is licensed under a Creative Commons Attribution 4.0 International License.
m4
General Information
DRACP ID DRACP00555
Peptide Name m4
Sequence LRRLDRWLRLFNRLRRWFLRLLRGL
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin membrane disrupting antimicrobial peptide KL15
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SW480 | Colon adenocarcinoma | Carcinoma | IC50=110 mg/ml | MTT assay | 24h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C158H261N55O29
Absent amino acids ACEHIKMPQSTVY
Common amino acids LR
Mass 382342
Pl 13.04
Basic residues 9
Acidic residues 1
Hydrophobic residues 13
Net charge 8
Boman Index -9380
Hydrophobicity -39.6
Aliphatic Index 140.4
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 11000
Absorbance 280nm 458.33
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 26147829
Title Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15
Doi 10.1080/15384047.2015.1056407
Year 2014
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.